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The Research: Benefits OF GINSENG

A Natural Aid for Muscle Wellness and Fatigue Relief

Ginseng, recognized for its medicinal properties, has attracted scientific interest for its role in improving muscle health and regulating energy. Recent studies have investigated the effects of various ginseng varieties, yielding important insights that may be particularly useful for those suffering from muscle deterioration or  chronic fatigue.

Scientifically Proven:

Ginseng as a Potential Solution for Chronic Fatigue

A study delved into whether an extract from P. ginseng roots, known as EEP, could help with chronic fatigue. The results were promising: EEP effectively reduced chronic fatigue in rats, pointing to P. ginseng as a possible dietary supplement for those looking to recover from persistent tiredness.

Addressing Muscle Disorders in the Elderly with Ginseng Treatments

Muscle disorders like sarcopenia are common in older adults. Research focusing on American wild ginseng pharmacopuncture (AWGP) and Korean cultivated wild ginseng pharmacopuncture (KCWGP) showed positive results. These ginseng treatments were found to increase the levels of proteins crucial for muscle growth and energy production, suggesting that ginseng could help strengthen muscle cells and enhance their energy efficiency. This is particularly beneficial for improving muscle function in the elderly.

Mountain Ginseng Against Muscle Loss

Muscle atrophy, often a side effect of medications like dexamethasone (DEXA), leads to the wasting away of muscles. Researchers investigated if mountain ginseng could be an effective countermeasure. The findings were encouraging: mountain ginseng not only reduced muscle loss but also improved the size and health of muscle cells. This was credited to its ability to lower the levels of proteins that cause muscle atrophy and increase those that support muscle health.

Important to Add:

Beyond its muscle health and anti-fatigue benefits, Ginseng offers a variety of other health advantages:

  • Cognitive Enhancement: Improves mental function and memory.
  • Immune System Support: Boosts immunity and may enhance vaccine responses.
  • Antioxidant Effects: Reduces oxidative stress.
  • Cardiovascular Health: Improves blood circulation and heart health.
  • Blood Sugar Control: Benefits insulin sensitivity and diabetes management.
  • Anti-inflammatory Action: Reduces inflammation.
  • Potential Anti-cancer Effects: May inhibit tumor growth.
  • Erectile Dysfunction Treatment: Shows positive results.
  • Menopausal Symptom Relief: Eases symptoms like hot flashes.
  • Stress and Anxiety Reduction: Helps manage stress and anxiety.

Scientific Research — 1

Mountain ginseng inhibits skeletal muscle atrophy by decreasing muscle RING finger protein-1 and atrogin1 through forkhead box O3 in L6 myotubes.


Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 24; Vol. 270, pp. 113557. Date of Electronic Publication: 2020 Nov 05.


Ethnopharmacological Relevance: Mountain ginseng (Panax ginseng C.A. Meyer) is a medicinal herb with immune effects, muscle damage protection and energy metabolism effects. However, the pharmacological role of mountain ginseng in dexamethasone (DEXA)-induced muscle atrophy through the forkhead box O (FOXO) family is not understood. Therefore, we hypothesized that mountain ginseng inhibits skeletal muscle atrophy by decreasing muscle RING finger protein-1 (MuRF1) and atrogin1 through FOXO3 in L6 myotubes.


These results suggest that mountain ginseng inhibits skeletal muscle atrophy by decreasing MuRF1 and atrogin1 through FOXO3a in L6 myotubes.

Scientific Research — 2

Effects of American wild ginseng and Korean cultivated wild ginseng pharmacopuncture extracts on the regulation of C2C12 myoblasts differentiation through AMPK and PI3K/Akt/mTOR signaling pathway.


Molecular medicine reports [Mol Med Rep] 2022 Jun; Vol. 25 (6). Date of Electronic Publication: 2022 Apr 08.


Targeting impaired myogenesis and mitochondrial biogenesis offers a potential alternative strategy for balancing energy to fight muscle disorders such as sarcopenia. In traditional Korean medicine, it is believed that the herb wild ginseng can help restore energy to the elderly. The present study investigated whether American wild ginseng pharmacopuncture (AWGP) and Korean cultivated wild ginseng pharmacopuncture (KCWGP) regulate energy metabolism in skeletal muscle cells. C2C12 mouse myoblasts were differentiated into myotubes using horse serum for 5 days. An MTT colorimetric assay verified cell viability. AWGP, KCWGP (0.5, 1, or 2 mg/ml), or metformin (2.5 mM) for reference were used to treat the C2C12 myotubes. The expressions of differentiation and mitochondrial biogenetic factors were measured by western blotting in C2C12 myotubes. Treatment of C2C12 cells stimulated with AWGP and KCWGP at a concentration of 10 mg/ml did not affect cell viability. AWGP and KCWGP treatments resulted in significant increases in the myogenesis proteins, myosin heavy chain, myostatin, myoblast determination protein 1 and myogenin, as well as increases to the biogenic regulatory factors, peroxisome proliferator‑activated receptor‑γ coactivator‑1‑α, nuclear respiratory factor 1, mitochondrial transcription factor A and Sirtuin 1, in the myotubes through AMPK and PI3K/AKT/mTOR signaling pathway activation. These results suggest that AWGP and KCWGP may be beneficial to muscle function by improving muscle differentiation and energy metabolism.

Scientific Research — 3

Panax ginseng improves physical recovery and energy utilization on chronic fatigue in rats through the PI3K/AKT/mTOR signalling pathway.


Pharmaceutical biology [Pharm Biol] 2023 Dec; Vol. 61 (1), pp. 316-323.

Primary Objective

This study investigated the antifatigue effect of P. ginseng on chronic fatigue rats.


The swimming times to exhaust of the rats with EEP were significantly longer than that without it. EEP spared the amount of muscle glycogen, hepatic glycogen and blood sugar under the chronic state. In addition, EEP significantly ( p  < 0.05) decreased serum triglycerides (1.24 ± 0.17, 1.29 ± 0.04 and 1.20 ± 0.21 vs. 1.58 ± 0.13 mmol/L) and total cholesterol (1.64 ± 0.36, 1.70 ± 0.15 and 1.41 ± 0.19 vs. 2.22 ± 0.19 mmol/L) compared to the model group. Regarding the regulation of energy, EEP had a positive impact on promoting ATPase activities and relative protein expression of the PI3K/Akt/mTOR pathway.


Our results suggested that EEP effectively relieved chronic fatigue, providing evidence that P. ginseng could be a potential dietary supplement to accelerate recovery from fatigue.

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